In this research project, our focus is on developing automated computer vision techniques for measuring/recognizing spontaneous facial expressions and FACS action units and map onto expert human coding. We apply developed automated techniques to analyze emotion expressions of children with autism. Autism is a severe early childhood developmental disorder that is characterized by deficits in cognitive performance as well as progressive qualitative impairments in social interactions. In the absence of a reliable biological marker, diagnosis of this devastating disorder is still based on its clinical manifestations. One of the clinical features of autism is difficulties in appropriately creating facial expressions that reflect child’s emotions.